www.visionparaiso.com A team of Italian researchers reported in the August 4 edition of Proceedings of the National Academy of Science (Act of the National Academy of Sciences), evidence shows that eye drops containing nerve growth factor improved the vision in three patients with advanced glaucoma
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The team of researchers Alessandro Lambiase, Luigi Aloe, Marco Centofanti, Vincenzo Pariso, Flavio Mantelli, Gilberto Bucci, Stefano Bonini, Rita Levi-Montalcini and evaluated Colofrancesco Valeria effects of eye drops based on "Nerve Growth Factor" in a rat glaucoma model and subsequently developed a clinical study of three patients with progressive visual field defects despite control eye pressure.
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Glaucoma was induced in rats by injection of hypertonic saline episcleral vein. Initially evaluated at 100 and 200 mg / mL on the results in 24 rats, determinándosa most effective dose of 200 mg / mL. A second group underwent histological, biochemical and molecular methods on a group treated for 7 weeks, bringing the best indices in relation to the control group. It was aimed at a slower loss of nerve fibers and cell death by apoptosis in the treated group versus the control group.
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The clinical study on three patients with advanced glaucoma treated psycho and electrofuncionales parameters analyzed after three months of treatment with topical "Nerve Growth Factor."
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treated patients showed a long-term improvement of visual field, optic nerve function, contrast sensitivity and visual acuity.
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Studies seem to show that the factor exerts neuroprotective effects Creimiento Nervous, inhibiting apoptosis in animals with glaucoma. In the 3 patients with advanced glaucoma with topical treatment "Nerve Growth Factor" improved all parameters of visual function.
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These results may open new therapeutic perspectives in the treatment of glaucoma and other neurodegenerative diseases of the optic nerve.
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Integrato di Ricerca Center, Department of Ophthalmology, University of Rome "Campus Bio-Medico" and Fondazione Alberto Sordi, 00128 Rome, Italy - Institute of Neurobiology and Molecular Medicine, National Research Council, 00143 Rome, Italy - Department of Ophthalmology, University of Rome "Tor Vergata", 00133 Rome, Italy - Gian Battista Bietti Eye Foundation, Rome, Italy - European Brain Research Institute Foundation, 00143 Rome, Italy.
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Basic information and guidance. For personalized information consult your ophthalmologist.
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