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Statins are a group of drugs commonly used to reduce cholesterol, protect against any damage that may result from heart disease and prevent heart attacks .
* Statins work by reducing plasma cholesterol and lipoproteins in the liver by inhibiting HMG-CoA reductase and increasing the cell surface the number of hepatic receptors for LDL. This will prevent the entry excessive amounts of cholesterol in the bloodstream.
*
now form a group of drugs prescribed on a common basis, and include lovastatin (Mevacor, Aterkey, Colesvir, Mevasterol, Nergadan, Taucor), simvastatin (Zocor, Alcosin, Arudel, Belmalip, Colemin, Glutasey, histopathologic, Inegy, Lipociden, Pantok) provastatina (Pravachol), fluvastatin (Lescol, Digaril, Lymetel, Vaditon, Liposit) and atorvastatin (Lipitor, Cardile, Prevencor, Zarator).
* em
The results of a recent study published in the journal Ophthalmology in December ( Ophthalmology . 2008, 115 (12) :2282-2285) suggest that some disorders of ocular motility and muscle such as diplopia, ptosis and ophthalmoplegia may be associated with statin therapy at normal doses.
*
Dr. FW Fraunfelder and Dr. Amanda B. Richards Casey Eye Institute, Oregon Health & Science University in Portland (USA) investigated the effects of this kind in their hospital care to several patients with diplopia and ptosis associated with statin therapy.
*
then collected cases in the National Registry of Drug-Induced Ocular Side Effects , WHO and the FDA. and identified in the database 256 patients (143 men, 91 women and 22 without gender specified) with diplopia, ptosis or ophthalmoplegia associated with statins.
*
The average patient age was 69 years. The dose varied among the different statins, although the average dose was within the limits recommended in the SPC of each drug. The median time to onset of the adverse effect of the drug was 8 months.
*
Of the 256 patients in 62 interrrumpido disorders disappeared with statin treatment. In Sixteen patients diplopia or ptosis reappeared on restart statin therapy. This suggests a provocative test is positive and convincing evidence of this adverse effect of statins.
*
Although this adverse effect is uncommon, probably represents a localized myositis in the extraocular muscles because statins can cause myositis in other skeletal muscles of the body, doctors who prescribed drugs in this class (statins) should know this possible adverse effects of the drug and assess the treatment interruption appears diploplia, ptosis or ophthalmoplegia.
* Statins work by reducing plasma cholesterol and lipoproteins in the liver by inhibiting HMG-CoA reductase and increasing the cell surface the number of hepatic receptors for LDL. This will prevent the entry excessive amounts of cholesterol in the bloodstream.
*
now form a group of drugs prescribed on a common basis, and include lovastatin (Mevacor, Aterkey, Colesvir, Mevasterol, Nergadan, Taucor), simvastatin (Zocor, Alcosin, Arudel, Belmalip, Colemin, Glutasey, histopathologic, Inegy, Lipociden, Pantok) provastatina (Pravachol), fluvastatin (Lescol, Digaril, Lymetel, Vaditon, Liposit) and atorvastatin (Lipitor, Cardile, Prevencor, Zarator).
* em
The results of a recent study published in the journal Ophthalmology in December ( Ophthalmology . 2008, 115 (12) :2282-2285) suggest that some disorders of ocular motility and muscle such as diplopia, ptosis and ophthalmoplegia may be associated with statin therapy at normal doses.
*
Dr. FW Fraunfelder and Dr. Amanda B. Richards Casey Eye Institute, Oregon Health & Science University in Portland (USA) investigated the effects of this kind in their hospital care to several patients with diplopia and ptosis associated with statin therapy.
*
then collected cases in the National Registry of Drug-Induced Ocular Side Effects , WHO and the FDA. and identified in the database 256 patients (143 men, 91 women and 22 without gender specified) with diplopia, ptosis or ophthalmoplegia associated with statins.
*
The average patient age was 69 years. The dose varied among the different statins, although the average dose was within the limits recommended in the SPC of each drug. The median time to onset of the adverse effect of the drug was 8 months.
*
Of the 256 patients in 62 interrrumpido disorders disappeared with statin treatment. In Sixteen patients diplopia or ptosis reappeared on restart statin therapy. This suggests a provocative test is positive and convincing evidence of this adverse effect of statins.
*
Although this adverse effect is uncommon, probably represents a localized myositis in the extraocular muscles because statins can cause myositis in other skeletal muscles of the body, doctors who prescribed drugs in this class (statins) should know this possible adverse effects of the drug and assess the treatment interruption appears diploplia, ptosis or ophthalmoplegia.
http://www.osnsupersite.com/view.aspx?rid=33934
http://www.eurekalert.org/pub_releases/2008-12/aaoo-od0112508. php
Basic information and guidance. For personalized information, see your ophthalmologist .
CEUTA EYES. INNOVATION IN OPHTHALMOLOGY.
Eye Center DR. CATOIRA MEDIN
Eyes Ceuta - Innovating Ophthalmology Ophthalmology Center Dr. MedÃn Catoira 
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